Health Risk Assessment Guidance for Metals • HERAG

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Metals are natural components of the earth and exist in many forms - each with its own specific chemical characteristics that define its interactions with the environment and with living organisms.

Typical risk assessments and guidance materials have been designed for organic chemicals and as such fail to take into consideration of metals specificities. This guidance looks to provides detailed advice needed to perform accurate health risk assessments for metals.

  1. Assessment of occupational dermal exposure and dermal absorption for metals and inorganic metal compounds.

  2. Assessment of occupational inhalation exposure and systemic inhalation absorption.

  3. Indirect exposure via the environment and consumer exposure.

  4. Gastrointestinal uptake and absorption, and catalogue of toxicokinetic models.

  5. Mutagenicity.

  6. Quality screening procedures for health effects literature.

  7. Essentiality.

  8. Choice of assessment factors in health risk assessment for metals.

Background document